Genetic Engineering: Principles and Methods: Volume 23

 Genetic Engineering at Amazon  Comments Off on Genetic Engineering: Principles and Methods: Volume 23
Nov 022015
 
Genetic Engineering: Principles and Methods: Volume 23
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Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allowed us to expand previously-recognized families and to identify dozens of new families. All of this work then led us to attempt to design a rational but comprehensive classification system that would be applicable to the complete complement of transport systems found in all living organisms (3). The classification system that we have devised is based primarily on mode of transport and energy coupling mechanism, secondarily on molecular phylogeny, and lastly on the substrate specificities of the individual permeases (4).

Genetic Engineering-Dream or Nightmare?: The Brave New World of Bad Science and Big Business

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Nov 012015
 
Genetic Engineering-Dream or Nightmare?: The Brave New World of Bad Science and Big Business
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Is genetic engineering a modern magic wand, responsible for producing fantastic crops to feed the world's hungry and a miracle cure-all for human disease? Or, as this book claims, is it an untried and inadequalty researched technology that is out of control with nightmarish results? The author aims to show how genetic determinism is at odds with the reality of scientific findings; gives rise to misguided practices and projects that are unethical and exploitative; and is hazardous to human and animal health and the ecological environment.